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FIGURE 3 TABLE 1 Mechanistic OSC classificationorigin, pharmacology, translational maturity, and safety considerations

For example, in the case of tau, abnormal tau triggers oxidative stress and mitochondrial defects such as mitochondrial depolarization, impaired mitochondrial complex activities and reduced energy output (326, 327)

1GL), indicating that GSH inhibition is a key factor promoting the sensitivity of VRK2-deficient cells to APR-017 and LCS3

A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4-chlorophenyl)thiazol-2-yl)hydrazone

Additionally, the issue is exacerbated by traditional laboratories setting the 'normal' range too low, which may result in undiagnosed B12 deficiencies